TargetMol

PACMA 31

Product Code:
 
TAR-T41277
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T41277-1mg1mg£103.00
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TAR-T41277-2mg2mg£118.00
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TAR-T41277-5mg5mg£148.00
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TAR-T41277-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T41277-10mg10mg£201.00
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TAR-T41277-25mg25mg£362.00
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TAR-T41277-50mg50mg£546.00
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TAR-T41277-100mg100mg£755.00
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TAR-T41277-500mg500mg£1,460.00
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Further Information

Bioactivity:
PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.
CAS:
1401089-31-3
Formula:
C21H22N2O6S
Molecular Weight:
430.47
Purity:
0.98
SMILES:
O=C(C#C)N(C1=CC=C(OC)C=C1OC)C(C(=O)NCC(=O)OCC)C=2SC=CC2

References

Xu S, et al. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012;109(40):16348-16353.