TargetMol

Nalfurafine

Product Code:
 
TAR-T41284
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-T41284-1mg1mg£222.00
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TAR-T41284-2mg2mg£293.00
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TAR-T41284-5mg5mg£386.00
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TAR-T41284-1mL1 mL * 10 mM (in DMSO)£507.00
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TAR-T41284-10mg10mg£541.00
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TAR-T41284-25mg25mg£825.00
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TAR-T41284-50mg50mg£1,091.00
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TAR-T41284-100mg100mg£1,452.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Nalfurafine is an effective and selective agonist of G protein-biased κ-opioid receptor with high translational potential. Nalfurafine enhances the therapeutic potential of MOR-targeting analgesics and can be used for uremic pruritis treatment studies.
CAS:
152657-84-6
Formula:
C28H32N2O5
Molecular Weight:
476.573
Pathway:
Endocrinology/Hormones; GPCR/G Protein; Neuroscience
Purity:
0.98
SMILES:
CN([C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CC1)c45)C(=O)C=Cc1ccoc1
Target:
Opioid Receptor

References

Endoh T, et al. Potent antinociceptive effects of TRK-820, a novel kappa-opioid receptor agonist.Life Sci. 1999;65(16):1685-94. Kaski SW, et al. Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine.J Pharmacol Exp Ther. 2019 Nov;371(2):487-499.