TargetMol

rac-BHFF

Product Code:
 
TAR-T4176
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4176-5mg5mg£115.00
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TAR-T4176-1mL1 mL * 10 mM (in DMSO)£139.00
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TAR-T4176-10mg10mg£148.00
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TAR-T4176-25mg25mg£229.00
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TAR-T4176-50mg50mg£334.00
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TAR-T4176-100mg100mg£470.00
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Quantity:
TAR-T4176-500mg500mg£938.00
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Further Information

Bioactivity:
Rac-BHFF is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). It exhibits anxiolytic activity in vivo and is orally active.
CAS:
123557-91-5
Formula:
C17H21F3O3
Molecular Weight:
330.347
Pathway:
Neuroscience; Membrane transporter/Ion channel
Purity:
1
SMILES:
CC(C)(C)c1cc2c(OC(=O)C2(O)C(F)(F)F)c(c1)C(C)(C)C
Target:
GABA Receptor

References

Koek W,et al.Discriminative Stimulus Effects of the GABAB Receptor-Positive Modulator rac-BHFF: Comparison with GABAB Receptor Agonists and Drugs of Abuse,J Pharmacol Exp Ther. 2013 Mar; 344(3): 553?560. Krishnamurthy S,et al. Crystal structure of (1R,4R)-tert-butyl 3-oxo-2-oxa-5-aza?bicyclo?[2.2.2]octane-5-carboxylate,Acta Crystallogr E Crystallogr Commun. 2015 Jul 1; 71(Pt 7): o449?o450.