TargetMol

PF-04929113 Mesylate

Product Code:
 
TAR-T4342
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4342-1mg1mg£128.00
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TAR-T4342-2mg2mg£152.00
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TAR-T4342-5mg5mg£201.00
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TAR-T4342-1mL1 mL * 10 mM (in DMSO)£267.00
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TAR-T4342-10mg10mg£314.00
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TAR-T4342-25mg25mg£424.00
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TAR-T4342-50mg50mg£591.00
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TAR-T4342-100mg100mg£813.00
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TAR-T4342-500mg500mg£1,572.00
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Further Information

Bioactivity:
PF-04929113 Mesylate, a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37 nM).
CAS:
1173111-67-5
Formula:
C26H34F3N5O7S
Molecular Weight:
617.64
Pathway:
Metabolism; Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling; JAK/STAT signaling
Purity:
0.9838
SMILES:
CS(O)(=O)=O.CC1(C)Cc2c(c(nn2-c2ccc(C(N)=O)c(NC3CCC(CC3)OC(=O)CN)c2)C(F)(F)F)C(=O)C1
Target:
HSP; HER

References

Chandarlapaty S, et al. SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers. Clin Cancer Res. 2008 Jan 1;14(1):240-8. Huang KH, et al. Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents. J Med Chem. 2009 Jul 23;52(14):4288-305 Okawa Y,etal.SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK.Blood. 2009 Jan 22;113(4):846-55. Kim SH, et al. The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. Endocrine. 2016 Feb;51(2):274-82.