TargetMol

RO1138452

Product Code:
 
TAR-T4436
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4436-1mg1mg£106.00
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TAR-T4436-2mg2mg£121.00
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TAR-T4436-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T4436-5mg5mg£148.00
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TAR-T4436-10mg10mg£195.00
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TAR-T4436-25mg25mg£349.00
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TAR-T4436-50mg50mg£550.00
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TAR-T4436-100mg100mg£755.00
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Further Information

Bioactivity:
RO1138452 is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1].
CAS:
221529-58-4
Formula:
C19H23N3O
Molecular Weight:
309.413
Pathway:
GPCR/G Protein; ; Immunology/Inflammation
Purity:
0.9573
SMILES:
CC(C)Oc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1
Target:
Prostaglandin Receptor

References

Clark R D, Jahangir A, Severance D, et al. Discovery and SAR development of 2-(phenylamino) imidazolines as postacyclin receptor antagonists[J]. Bioorganic & medicinal chemistry letters, 2004, 14(4): 1053-1056.