TargetMol

GIBH-130

Product Code:
 
TAR-T4450
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4450-1mg1mg£101.00
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TAR-T4450-2mg2mg£114.00
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TAR-T4450-5mg5mg£141.00
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TAR-T4450-1mL1 mL * 10 mM (in DMSO)£156.00
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TAR-T4450-10mg10mg£195.00
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TAR-T4450-25mg25mg£346.00
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TAR-T4450-50mg50mg£523.00
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TAR-T4450-100mg100mg£691.00
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This product comes from: United States.
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Further Information

Bioactivity:
GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
CAS:
1252608-59-5
Formula:
C20H20N6O
Molecular Weight:
360.421
Pathway:
Apoptosis; Immunology/Inflammation
Purity:
0.9986
SMILES:
Cc1cc(nnc1C(=O)N1CCN(CC1)c1ncccn1)-c1ccccc1
Target:
IL Receptor; TNF; Interleukin

References

Zhou W, Zhong G, Fu S, et al. Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer's Disease Models[J]. Acs Chemical Neuroscience, 2016, 7(11):1499-1507.