TargetMol

Pyridostatin Trihydrochloride

Product Code:
 
TAR-T4457
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T4457-1mg1mg£99.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T4457-2mg2mg£108.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T4457-5mg5mg£130.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T4457-10mg10mg£161.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T4457-25mg25mg£232.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T4457-50mg50mg£315.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T4457-100mg100mg£483.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM.
CAS:
T4457
Formula:
C31H35Cl3N8O5
Molecular Weight:
706.02
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.98
SMILES:
Cl.Cl.Cl.NCCOc1cc(nc(c1)C(=O)Nc1cc(OCCN)c2ccccc2n1)C(=O)Nc1cc(OCCN)c2ccccc2n1
Target:
DNA/RNA Synthesis

References

Rodriguez R,etal.Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.Nat Chem Biol. 2012 Feb 5;8(3):301-10. Moruno-Manchon JF,etal.The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons.Aging (Albany NY). 2017 Sep 12;9(9):1957-1970. Koirala D,etal.A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.Nat Chem. 2011 Aug 28;3(10):782-7. Wang J, Huang H, Zhao K, et al.G-quadruplex in Hepatitis B Virus pregenomic RNA Promotes its Translation.Journal of Biological Chemistry.2023: 105151. Li C, Yin Z, Xiao R, et al.G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes.Genome Biology.2022, 23(1): 1-29.