TargetMol

Rucaparib

Product Code:
 
TAR-T4463
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4463-2mg2mg£103.00
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TAR-T4463-5mg5mg£124.00
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TAR-T4463-1mL1 mL * 10 mM (in DMSO)£130.00
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TAR-T4463-10mg10mg£164.00
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TAR-T4463-25mg25mg£217.00
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TAR-T4463-50mg50mg£269.00
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TAR-T4463-100mg100mg£378.00
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TAR-T4463-200mg200mg£527.00
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TAR-T4463-500mg500mg£805.00
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Further Information

Bioactivity:
Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP.
CAS:
283173-50-2
Formula:
C19H18FN3O
Molecular Weight:
323.371
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.9989
SMILES:
CNCc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23
Target:
PARP

References

Daniel RA,etal.Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.Clin Cancer Res. 2009 Feb 15;15(4):1241-9. Thomas HD,etal.Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.Mol Cancer Ther. 2007 Mar;6(3):945-56. Daniel RA,etal.Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.Br J Cancer. 2010 Nov 9;103(10):1588-96. Hunter JE,etal.NF-?B mediates radio-sensitization by the PARP-1 inhibitor, AG-2014699.Oncogene. 2012 Jan 12;31(2):251-64.