TargetMol

NMS-P118

Product Code:
 
TAR-T4472
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4472-1mg1mg£107.00
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TAR-T4472-2mg2mg£124.00
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TAR-T4472-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T4472-5mg5mg£164.00
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TAR-T4472-10mg10mg£229.00
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TAR-T4472-25mg25mg£389.00
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TAR-T4472-50mg50mg£550.00
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TAR-T4472-100mg100mg£768.00
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This product comes from: United States.
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Further Information

Bioactivity:
NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy.
CAS:
1262417-51-5
Formula:
C20H24F3N3O2
Molecular Weight:
395.426
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.9887
SMILES:
NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C3CCC(F)(F)CC3)C(=O)c12
Target:
PARP

References

Papeo G, et al. Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. J Med Chem. 2015 Sep 10;58(17):6875-98.