TargetMol

Rimegepant

Product Code:
 
TAR-T4610
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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CodeSizePrice
TAR-T4610-1mg1mg£111.00
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TAR-T4610-5mg5mg£149.00
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TAR-T4610-1mL1 mL * 10 mM (in DMSO)£181.00
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TAR-T4610-10mg10mg£201.00
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TAR-T4610-25mg25mg£338.00
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Quantity:
TAR-T4610-50mg50mg£468.00
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Quantity:
TAR-T4610-100mg100mg£648.00
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Quantity:
TAR-T4610-500mg500mg£1,267.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
CAS:
1289023-67-1
Formula:
C28H28F2N6O3
Molecular Weight:
534.568
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.9933
SMILES:
N[C@H]1[C@@H](CC[C@@H](OC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)c2ncccc12)c1cccc(F)c1F
Target:
CGRP Receptor

References

Sun K, Zhu J, Yan C, et al. CGRP Regulates Nucleus Pulposus Cell Apoptosis and Inflammation via the MAPK/NF-?B Signaling Pathways during Intervertebral Disc Degeneration. Oxidative Medicine and Cellular Longevity. 2021, 2021. Zheng N, et al. Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS. J Pharm Biomed Anal. 2014 Feb;89:240-50. Luo G, et al. Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) a