TargetMol

R-7050

Product Code:
 
TAR-T4637
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4637-2mg2mg£101.00
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TAR-T4637-5mg5mg£119.00
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TAR-T4637-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T4637-10mg10mg£148.00
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TAR-T4637-25mg25mg£245.00
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TAR-T4637-50mg50mg£309.00
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TAR-T4637-100mg100mg£462.00
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TAR-T4637-500mg500mg£922.00
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This product comes from: United States.
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Further Information

Bioactivity:
R-7050 is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.
CAS:
303997-35-5
Formula:
C16H8ClF3N4S
Molecular Weight:
380.77
Pathway:
Apoptosis
Purity:
0.9914
SMILES:
FC(F)(F)c1nnc2c(Sc3ccccc3)nc3ccc(Cl)cc3n12
Target:
TNF

References

Gururaja TL, et al. A class of small molecules that inhibit TNFalpha-induced survival and death pathways viaprevention of interactions between TNFalphaRI, TRADD, and RIP1. Chem Biol. 2007 Oct;14(10):1105-18. King MD, et al. TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebralhemorrhage in mice. Neurosci Lett. 2013 May 10;542:92-6. Yi Y, Gao K, Lin P, et al. Staphylococcus aureus-Induced Necroptosis Promotes Mitochondrial Damage in Goat Endometrial Epithelial Cells. Animals. 2022, 12(17): 2218.