TargetMol

M2I-1

Product Code:
 
TAR-T4647
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4647-1mg1mg£106.00
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TAR-T4647-2mg2mg£122.00
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TAR-T4647-5mg5mg£168.00
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TAR-T4647-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T4647-10mg10mg£230.00
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TAR-T4647-25mg25mg£436.00
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TAR-T4647-50mg50mg£610.00
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TAR-T4647-100mg100mg£838.00
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Quantity:
TAR-T4647-500mg500mg£1,613.00
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Further Information

Bioactivity:
M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. It can also inhibited the Mad2-F-Mbp1 interaction in FP assays.
CAS:
312271-03-7
Formula:
C19H24N4O4S
Molecular Weight:
404.49
Purity:
1
SMILES:
CC(C)CN(CC(C)C)c1ccc(C=C2C(=O)NC(=S)NC2=O)cc1[N+]([O-])=O

References

Johanna Kastl et al. Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint. ACS Chem. Biol., 2015, 10 (7), pp 1661-1666.