TargetMol

C188-9

Product Code:
 
TAR-T4650
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4650-1mg1mg£101.00
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TAR-T4650-2mg2mg£114.00
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TAR-T4650-5mg5mg£142.00
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TAR-T4650-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T4650-10mg10mg£171.00
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TAR-T4650-25mg25mg£282.00
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TAR-T4650-50mg50mg£406.00
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TAR-T4650-100mg100mg£573.00
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TAR-T4650-500mg500mg£1,139.00
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This product comes from: United States.
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Further Information

Bioactivity:
C188-9 is a Stat3 inhibitor with an IC50 of 4-7 μM.
CAS:
432001-19-9
Formula:
C27H21NO5S
Molecular Weight:
471.53
Pathway:
JAK/STAT signaling; Apoptosis; Stem Cells
Purity:
0.9807
SMILES:
COc1ccc(cc1)S(=O)(=O)Nc1cc(c(O)c2ccccc12)-c1c(O)ccc2ccccc12
Target:
Apoptosis; STAT

References

Bharadwaj U, et al. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 3;7(18):26307-30. Gu H, Chen C, Hao X, et al. MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells. Blood. 2020, 136(5): 553-571. He Q R, Tang J J, Chen Z F, et al. Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer[J]. Authorea Preprints. 2020 He, Qiu?Rui, et al. The natural product trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer. British Journal of Pharmacology. ?178.12 (2021): 2496-2515. Gu H, Chen C, Hao X, et al. MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells[J]. Blood. 2021, 137(11): 1478-1490. edell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011 May 26;117(21):5701-9. Guan X, Yang J, Wang W, et al.Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer.Pharmacological Research.2023: 106703.