TargetMol

TCS-OX2-29

Product Code:
 
TAR-T4965
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4965-2mg2mg£102.00
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TAR-T4965-5mg5mg£122.00
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TAR-T4965-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T4965-10mg10mg£148.00
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TAR-T4965-25mg25mg£222.00
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TAR-T4965-50mg50mg£294.00
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TAR-T4965-100mg100mg£470.00
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Further Information

Bioactivity:
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
CAS:
372523-75-6
Formula:
C23H31N3O3
Molecular Weight:
397.519
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.9908
SMILES:
COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H](NCc1ccncc1)C(C)(C)C
Target:
OX Receptor

References

Hirose M et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidicantagonist. Bioorg Med Chem Lett, 2003 Dec 15, 13(24):4497-9. R Mould et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol. 2014 Jan; 171(2): 351-363.