TargetMol

SRT 1720

Product Code:
 
TAR-T5096
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5096-2mg2mg£97.00
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TAR-T5096-5mg5mg£113.00
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TAR-T5096-10mg10mg£138.00
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TAR-T5096-1mL1 mL * 10 mM (in DMSO)£144.00
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TAR-T5096-25mg25mg£205.00
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TAR-T5096-50mg50mg£329.00
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TAR-T5096-100mg100mg£438.00
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Further Information

Bioactivity:
SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.
CAS:
925434-55-5
Formula:
C25H23N7OS
Molecular Weight:
469.57
Pathway:
Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
Purity:
0.997
SMILES:
O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1
Target:
Sirtuin; Autophagy

References

Yu L, et al. Protective effects of SRT1720 via the HNF1?/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury. Toxicol Lett. 2016 Dec 15;264:1-11. Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6 Wu Q, Hu Y, Jiang M, et al. Effect of Autophagy Regulated by Sirt1/FoxO1 Pathway on the Release of Factors Promoting Thrombosis from Vascular Endothelial Cells. International journal of molecular sciences. 2019, 20(17): 4132. Chauhan D, et al. Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells. Br J Haematol. 2011 Dec;155(5):588-98. Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.,J Clin Invest. 2012 Jun 1;122(6):2032-45. Wu Q, Hu Y, Jiang M, et al. Effect of Autophagy Regulated by Sirt1/FoxO1 Pathway on the Release of Factors Promoting Thrombosis from Vascular Endothelial Cells[J]. International journal of molecular sciences. 2019, 20(17): 4132. Lian L, Le Z, Wang Z, et al.SIRT1 Inhibits High Glucose?Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation.Investigative Ophthalmology & Visual Science.2023, 64(3): 16-16.