TargetMol

NAV-2729

Product Code:
 
TAR-T5142
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5142-2mg2mg£101.00
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TAR-T5142-5mg5mg£119.00
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TAR-T5142-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T5142-10mg10mg£148.00
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TAR-T5142-25mg25mg£245.00
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TAR-T5142-50mg50mg£341.00
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TAR-T5142-100mg100mg£470.00
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TAR-T5142-500mg500mg£978.00
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Further Information

Bioactivity:
NAV-2729 inhibits six ArfGEFs (human ARNO, EFA6, BIG1, and BRAG2 and Legionella and Rickettsia RalF), the strongest effects being against BRAG2, Arf1 and Arf6.
CAS:
419547-11-8
Formula:
C25H17ClN4O3
Molecular Weight:
456.89
Pathway:
; GPCR/G Protein
Purity:
0.9883
SMILES:
[O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3ccc(Cl)cc3)c2[nH]1
Target:
GTPase

References

Benabdi S, et al. Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles. Biochemistry. 2017 Sep 26;56(38):5125-5133. Yamauchi Y, et al. Machineries regulating the activity of the small GTPase Arf6 in cancer cells are potential targets for developing innovative anti-cancer drugs. Adv Biol Regul. 2017 Jan;63:115-121.