TargetMol

Cabozantinib hydrochloride

Product Code:
 
TAR-T5164
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5164-1mg1mg£100.00
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TAR-T5164-2mg2mg£111.00
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TAR-T5164-5mg5mg£121.00
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TAR-T5164-10mg10mg£149.00
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TAR-T5164-25mg25mg£209.00
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TAR-T5164-50mg50mg£279.00
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TAR-T5164-100mg100mg£365.00
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TAR-T5164-200mg200mg£551.00
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TAR-T5164-500mg500mg£838.00
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This product comes from: United States.
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Further Information

Bioactivity:
Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
CAS:
1817759-42-4
Formula:
C28H25ClFN3O5
Molecular Weight:
537.96
Pathway:
Tyrosine Kinase/Adaptors; Metabolism; Angiogenesis
Purity:
0.9972
SMILES:
Cl.COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
Target:
VEGFR; FLT; c-Met/HGFR; TAM Receptor; c-Kit; ROR

References

Torres KE, et al. Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors.Clin Cancer Res. 2011 Jun 15;17(12):3943-55. Yakes FM, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther, 2011, 10(12), 2298-2308. You WK, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res, 2011, 71(14), 4758-4768.