TargetMol

GS-444217

Product Code:
 
TAR-T5190
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5190-1mg1mg£103.00
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TAR-T5190-5mg5mg£142.00
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TAR-T5190-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T5190-10mg10mg£177.00
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TAR-T5190-25mg25mg£252.00
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TAR-T5190-50mg50mg£389.00
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TAR-T5190-100mg100mg£550.00
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This product comes from: United States.
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Further Information

Bioactivity:
GS-444217 is a selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50: 2.87 nM).
CAS:
1262041-49-5
Formula:
C23H21N7O
Molecular Weight:
411.469
Pathway:
Apoptosis; MAPK
Purity:
0.9958
SMILES:
O=C(Nc1cccc(c1)-c1nncn1C1CC1)c1cc(ccn1)-n1cnc(c1)C1CC1
Target:
Apoptosis; ASK; MAPK

References

Tesch GH, et al. ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice. Diabetes. 2015 Nov;64(11):3903-13. Liles JT, et al. ASK1 contributes to fibrosis and dysfunction in models of kidney disease. J Clin Invest. 2018 Oct 1;128(10):4485-4500.