TargetMol

Radiprodil

Product Code:
 
TAR-T5385
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5385-1mg1mg£103.00
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TAR-T5385-2mg2mg£118.00
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TAR-T5385-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T5385-5mg5mg£148.00
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TAR-T5385-10mg10mg£195.00
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TAR-T5385-25mg25mg£308.00
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TAR-T5385-50mg50mg£510.00
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TAR-T5385-100mg100mg£704.00
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This product comes from: United States.
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Further Information

Bioactivity:
Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP).
CAS:
496054-87-6
Formula:
C21H20FN3O4
Molecular Weight:
397.406
Pathway:
Neuroscience; Membrane transporter/Ion channel
Purity:
0.999
SMILES:
Fc1ccc(CC2CCN(CC2)C(=O)C(=O)Nc2ccc3[nH]c(=O)oc3c2)cc1
Target:
NMDAR; iGluR

References

Labas R, et al. Synthesis, evaluation and metabolic studies of radiotracers containing a 4-(4-[18F]-fluorobenzyl)piperidin-1-yl moiety for the PET imaging of NR2B NMDA receptors. Eur J Med Chem. 2011 Jun;46(6):2295-309. Rammes G, et al. The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (A?) species on long-term potentiation (LTP). Neuropharmacology. 2018 Sep 15;140:184-192.