TargetMol

A-381393

Product Code:
 
TAR-T5397
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5397-1mg1mg£115.00
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TAR-T5397-2mg2mg£134.00
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TAR-T5397-5mg5mg£168.00
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TAR-T5397-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T5397-10mg10mg£230.00
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TAR-T5397-25mg25mg£367.00
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TAR-T5397-50mg50mg£497.00
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TAR-T5397-100mg100mg£687.00
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Further Information

Bioactivity:
A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
CAS:
726174-00-1
Formula:
C20H24N4
Molecular Weight:
320.44
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.9992
SMILES:
Cc1ccc(cc1C)N1CCN(Cc2nc3ccccc3[nH]2)CC1
Target:
Dopamine Receptor

References

Bitner RS, et al. Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation. Neuropharmacology. 2006 Apr;50(5):521-31. Nakane M, et al. 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49(1):112-21.