TargetMol

AMG 333

Product Code:
 
TAR-T5479
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5479-1mg1mg£95.00
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TAR-T5479-2mg2mg£106.00
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TAR-T5479-5mg5mg£128.00
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TAR-T5479-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T5479-10mg10mg£173.00
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TAR-T5479-25mg25mg£277.00
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TAR-T5479-50mg50mg£402.00
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TAR-T5479-100mg100mg£544.00
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This product comes from: United States.
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Further Information

Bioactivity:
AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.
CAS:
1416799-28-4
Formula:
C20H12F5N3O4
Molecular Weight:
453.325
Pathway:
Membrane transporter/Ion channel
Purity:
0.9908
SMILES:
OC(=O)c1ccc(nc1)C(=O)N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)c1ncccc1F
Target:
TRP/TRPV Channel

References

Horne DB, et al. Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61(18):8186-8201.