TargetMol

BI-4464

Product Code:
 
TAR-T5480
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5480-1mg1mg£119.00
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TAR-T5480-2mg2mg£139.00
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TAR-T5480-5mg5mg£189.00
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TAR-T5480-10mg10mg£262.00
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TAR-T5480-25mg25mg£389.00
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TAR-T5480-50mg50mg£544.00
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Quantity:
TAR-T5480-100mg100mg£760.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
CAS:
1227948-02-8
Formula:
C28H28F3N5O4
Molecular Weight:
555.558
Pathway:
Cytoskeletal Signaling; Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.9743
SMILES:
COc1cc(ccc1Nc1ncc(c(Oc2cccc3CCC(=O)c23)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Target:
FAK

References

Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.