TargetMol

RU.521

Product Code:
 
TAR-T5486
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5486-1mg1mg£103.00
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TAR-T5486-2mg2mg£117.00
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TAR-T5486-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T5486-5mg5mg£148.00
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TAR-T5486-10mg10mg£209.00
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TAR-T5486-25mg25mg£296.00
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TAR-T5486-50mg50mg£389.00
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TAR-T5486-100mg100mg£544.00
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Further Information

Bioactivity:
RU.521 (RU320521) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
CAS:
2262452-06-0
Formula:
C19H12Cl2N4O3
Molecular Weight:
415.23
Pathway:
Immunology/Inflammation; DNA Damage/DNA Repair
Purity:
0.9982
SMILES:
Cc1nn(c(O)c1C1OC(=O)c2ccccc12)-c1nc2ccc(Cl)c(Cl)c2[nH]1
Target:
DNA; cGAS

References

Vincent J, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.