TargetMol

L-765314

Product Code:
 
TAR-T5511
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5511-1mg1mg£103.00
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TAR-T5511-2mg2mg£116.00
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TAR-T5511-5mg5mg£142.00
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TAR-T5511-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T5511-10mg10mg£189.00
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TAR-T5511-25mg25mg£301.00
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TAR-T5511-50mg50mg£436.00
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TAR-T5511-100mg100mg£610.00
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Further Information

Bioactivity:
L-765314 is a drug which acts as a potent and selective antagonist for the Alpha-1 adrenergic receptor subtype α1B. It has mainly been used to investigate the role of α1B receptors in the regulation of blood pressure.
CAS:
189349-50-6
Formula:
C27H34N6O5
Molecular Weight:
522.606
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.9995
SMILES:
COc1cc2nc(nc(N)c2cc1OC)N1CCN([C@@H](C1)C(=O)NC(C)(C)C)C(=O)OCc1ccccc1
Target:
Adrenergic Receptor

References

Kim J , Kim Y H , Bang S , et al. L-765,314 Suppresses Melanin Synthesis by Regulating Tyrosinase Activity[J]. Molecules, 2019, 24(4). Patane MA, et al. 4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist. J Med Chem. 1998 Apr 9;41(8):1205-8. Tobias B?hmer, et al. The ?1B-adrenoceptor subtype mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium. Br J Pharmacol. 2014 Aug; 171(16): 3858?3867.