TargetMol

LY-411575

Product Code:
 
TAR-T6063
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6063-2mg2mg£101.00
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TAR-T6063-5mg5mg£119.00
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TAR-T6063-1mL1 mL * 10 mM (in DMSO)£121.00
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TAR-T6063-10mg10mg£156.00
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TAR-T6063-25mg25mg£249.00
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TAR-T6063-50mg50mg£417.00
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TAR-T6063-100mg100mg£584.00
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This product comes from: United States.
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Further Information

Bioactivity:
LY411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM.
CAS:
209984-57-6
Formula:
C26H23F2N3O4
Molecular Weight:
479.484
Pathway:
Stem Cells; Proteases/Proteasome; Apoptosis; Neuroscience
Purity:
0.9938
SMILES:
C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@H]1c2ccccc2-c2ccccc2N(C)C1=O
Target:
Apoptosis; Gamma-secretase

References

Hyde LA, et al, J Pharmacol Exp Ther, 2006, 319(3), 1133-1143. Wong GT, et al, J Biol Chem, 2004, 279(13), 12876-12882. Yang D L, Zhang Y, He L, et al. Demethylzeylasteral (T-96) Initiates Extrinsic Apoptosis Against Prostate Cancer cells by Inducing ROS-Mediated ER Stress and Suppressing Autophagic Flux. Biological Research. 2021, 54(1): 1-14. Yang D L, Zhang Y, He L, et al. Demethylzeylasteral (T-96) Initiates Extrinsic Apoptosis Against Prostate Cancer cells by Inducing ROS-Mediated ER Stress and Suppressing Autophagic Flux[J]. 2021 Curry CL, et al, Oncogene, 2005, 24(42), 6333-6344. Zhang S, Lou H, Lu H, et al.Characterization of Proliferation Medium and Its Effect on Differentiation of Muscle Satellite Cells from Larimichthys crocea in Cultured Fish Meat Production.Fishes.2023, 8(9): 429.