TargetMol

PF-543

Product Code:
 
TAR-T6085
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6085-2mg2mg£111.00
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TAR-T6085-5mg5mg£133.00
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TAR-T6085-1mL1 mL * 10 mM (in DMSO)£139.00
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TAR-T6085-10mg10mg£164.00
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TAR-T6085-25mg25mg£246.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
CAS:
1415562-82-1
Formula:
C27H31NO4S
Molecular Weight:
465.61
Pathway:
Apoptosis; Autophagy; GPCR/G Protein
Purity:
0.98
SMILES:
Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc(CN3CCC[C@@H]3CO)cc2)c1
Target:
Apoptosis; S1P Receptor; Autophagy; LPL Receptor

References

Schnute ME, et al. Biochem J, 2012, 444(1), 79-88. MacRitchie N, et al. Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cell Signal. 2016 Aug;28(8):946-55.