TargetMol

Gambogic Acid

Product Code:
 
TAR-T6185
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T6185-1mL1 mL * 10 mM (in DMSO)£135.00
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TAR-T6185-20mg20mg£151.00
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Further Information

Bioactivity:
Gambogic Acid ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively.
CAS:
2752-65-0
Formula:
C38H44O8
Molecular Weight:
628.762
Pathway:
Autophagy; Apoptosis
Purity:
0.9838
SMILES:
CC(C)=CCC[C@@]1(C)Oc2c(CC=C(C)C)c3O[C@@]45[C@H]6C[C@@H](C=C4C(=O)c3c(O)c2C=C1)C(=O)[C@]5(CC=C(C)C(O)=O)OC6(C)C
Target:
BCL; Autophagy

References

Zhai D, et al. Mol Cancer Ther, 2008, 7(6), 1639-1646. Zhang HZ, et al. Bioorg Med Chem, 2004, 12(2), 309-317. Pandey MK, et al. Blood, 2007, 110(10), 3517-3525. Yi T, et al. Cancer Res. 2008 Mar 15;68(6):1843-50. Liu X, Hu Q, Wang W, et al. A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ER? mutants in breast cancer. Biochemical Pharmacology. 2021, 188: 114583. Wang X, et al. Anticancer Agents Med Chem, 2012, 12(8), 1994-12000.