TargetMol

Tipifarnib

Product Code:
 
TAR-T6271
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6271-1mg1mg£98.00
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TAR-T6271-2mg2mg£109.00
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TAR-T6271-5mg5mg£132.00
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TAR-T6271-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T6271-10mg10mg£177.00
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TAR-T6271-25mg25mg£274.00
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TAR-T6271-50mg50mg£438.00
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Further Information

Bioactivity:
Tipifarnib is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis.
CAS:
192185-72-1
Formula:
C27H22Cl2N4O
Molecular Weight:
489.4
Pathway:
Metabolism
Purity:
0.9922
SMILES:
Cn1cncc1[C@@](N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Target:
Transferase

References

Martin LA, et al. Mol Cancer Ther. 2007, 6(9), 2458-2467. Kotsianidis I, et al. Acta Haematol. 2008, 120(1), 51-56. Krzykowska-Petitjean K, et al. J Cancer Res Clin Oncol. 2012, 138(3), 537-544. Bai F, et al. Cancer Immunol Immunother. 2012, 61(4), 523-533. Margolin KA, et al. Clin Cancer Res. 2012, 18(4), 1129-1137.