TargetMol

Vadimezan

Product Code:
 
TAR-T6273
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6273-2mg2mg£109.00
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TAR-T6273-5mg5mg£136.00
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TAR-T6273-1mL1 mL * 10 mM (in DMSO)£143.00
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TAR-T6273-10mg10mg£159.00
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TAR-T6273-25mg25mg£262.00
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TAR-T6273-50mg50mg£417.00
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Quantity:
TAR-T6273-100mg100mg£452.00
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Further Information

Bioactivity:
Vadimezan is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages.
CAS:
117570-53-3
Formula:
C17H14O4
Molecular Weight:
282.295
Pathway:
Immunology/Inflammation; Microbiology/Virology; Angiogenesis
Purity:
0.998
SMILES:
Cc1ccc2c(oc3c(CC(O)=O)cccc3c2=O)c1C
Target:
Influenza Virus; VDA; STING; IFNAR

References

Liu JJ, et al. Cancer Chemother Pharmacol. 2007, 59(5), 661-669. Zhao M, Wang B, Zhang C, et al. The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson?s disease[J]. Cell Death & Differentiation. 2021: 1-19. Buchanan CM, et al. Clin Sci (Lond). 2012, 122(10), 449-457. Shirey KA, et al. J Leukoc Biol. 2011, 89(3), 351-357. Chen C, Zhang Y, Tao M, et al. Atrial Natriuretic Peptide Attenuates Colitis via Inhibition of the cGAS-STING Pathway in Colonic Epithelial Cells. International Journal of Biological Sciences. 2022, 18(4): 1737-1754. Chen C, Yan W, Zhang Y, et al. ANP Attenuates Intestinal Inflammation by Regulating STING Pathway[J]. Available at SSRN 3756807. Phillips RM. Biochem Pharmacol. 1999, 58(2), 303-310. Zhao M, Wang B, Zhang C, et al. The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson?s disease. Cell Death & Differentiation. 2021: 1-19.