TargetMol

Obatoclax Mesylate

Product Code:
 
TAR-T6275
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6275-5mg5mg£105.00
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TAR-T6275-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T6275-10mg10mg£125.00
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TAR-T6275-25mg25mg£172.00
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TAR-T6275-50mg50mg£251.00
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TAR-T6275-100mg100mg£374.00
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Further Information

Bioactivity:
Obatoclax is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.
CAS:
803712-79-0
Formula:
C21H23N3O4S
Molecular Weight:
413.49
Pathway:
Autophagy; Apoptosis; Microbiology/Virology
Purity:
0.9967
SMILES:
CS(O)(=O)=O.COC1=CC(=NC1=Cc1[nH]c(C)cc1C)c1cc2ccccc2[nH]1
Target:
BCL; Parasite; Autophagy

References

Huang S, et al. BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells. Clin Cancer Res. 2009 Jan 1;15(1):150-9. Champa D, et al. Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis. Oncotarget. 2016 Jun 7;7(23):34453-71. Nguyen M, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7. Epub 2007 Nov 26. Wei WJ, et al. Obatoclax and LY3009120 Efficiently Overcome RG7204 Resistance in Differentiated Thyroid Cancer. Theranostics. 2017 Feb 23;7(4):987-1001. Konopleva M, et al. Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax). Cancer Res May 1, 2008 68; 3413