TargetMol

Wortmannin

Product Code:
 
TAR-T6283
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T6283-50mg50mgEnquire
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TAR-T6283-1mg1mg£96.00
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TAR-T6283-2mg2mg£107.00
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TAR-T6283-5mg5mg£128.00
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TAR-T6283-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T6283-10mg10mg£148.00
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TAR-T6283-25mg25mg£230.00
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Further Information

Bioactivity:
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM.
CAS:
19545-26-7
Formula:
C23H24O8
Molecular Weight:
428.437
Pathway:
Autophagy; Microbiology/Virology; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Cell Cycle/Checkpoint
Purity:
0.9976
SMILES:
[H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)c2occ3c2[C@]1(C)[C@@H](COC)OC3=O
Target:
ATM/ATR; DNA-PK; Serine/threonin kinase; PLK; PI3K; Antibiotic; Autophagy

References

Wang T, Wang L, Li W, et al.Fowl adenovirus serotype 4 enters leghorn male hepatocellular cells via the clathrin-mediated endocytosis pathway.Veterinary Research.2023, 54(1): 1-14. Wang H, Ye J, Peng Y, et al.CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.Autophagy.2023 (just-accepted). Wang C, Wang T, Hu R, et al.9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3? and HSP90?.Journal of Virology.2023: e01984-22. Gao Y, Xiong J, Chu Q Z, et al. PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth. Journal of Cell Science. 2022 Mar 1;135(5):jcs255026. doi: 10.1242/jcs.255026. Epub 2021 Apr 20. Arcaro A, et al. Biochem J, 1993, 296(Pt 2), 297-301. Han H W, Hahn S, Jeong H Y, et al. LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent[J]. Scientific reports. 2018 Oct 8;8(1):14969. Han H W, Hahn S, Jeong H Y, et al. LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent. Scientific Reports. 2018 Oct 8;8(1):14969 Nakanishi S, et al. J Biol Chem, 1992, 267(4), 2157-2163. Zhang H, Cui Z, Cheng D, et al. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis[J]. Autophagy . 2020 Gao Y, Xiong J, Chu Q Z, et al. PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth[J]. Journal of Cell Science. 2021, 135(5): jcs255026. Zhang H, Cui Z, Cheng D, et al. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis. Autophagy. 2021 Oct;17(10):3030-3047 Ly T T G, Yun J, Ha J S, et al. Inhibitory Effect of Etravirine, a Non-Nucleoside Reverse Transcriptase Inhibitor, via Anterior Gradient Protein 2 Homolog Degradation against Ovarian Cancer Metastasis. International Journal of Molecular Sciences. 2022, 23(2): 944.