TargetMol

Vactosertib

Product Code:
 
TAR-T6496
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6496-2mg2mg£102.00
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TAR-T6496-5mg5mg£122.00
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TAR-T6496-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T6496-10mg10mg£148.00
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TAR-T6496-25mg25mg£201.00
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TAR-T6496-50mg50mg£275.00
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TAR-T6496-100mg100mg£386.00
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TAR-T6496-200mg200mg£538.00
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TAR-T6496-500mg500mg£804.00
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This product comes from: United States.
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Further Information

Bioactivity:
Vactosertib is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potential antineoplastic activity.
CAS:
1352608-82-2
Formula:
C22H18FN7
Molecular Weight:
399.433
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; Stem Cells
Purity:
0.9978
SMILES:
Cc1cccc(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
Target:
ALK; TGF-beta/Smad

References

Kalli M, Mpekris F, Wong C K, et al. Activin A signaling regulates IL13R?2 expression to promote breast cancer metastasis[J]. Frontiers in oncology. 2019 Feb 5;9:32. Son JY, et al. Mol Cancer Ther. 2014, 13(7), 1704-1716. Jin CH, et al. J Med Chem. 2014, 57(10), 4213-4238. Yoon JH, et al. EMBO Mol Med. 2013, 5(11), 1720-1739. Kalli M, Mpekris F, Wong C K, et al. Activin A signaling regulates IL13R?2 expression to promote breast cancer metastasis. Frontiers in Oncology. 2019 Feb 5;9:32