TargetMol

FIIN-2

Product Code:
 
TAR-T6836
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6836-1mg1mg£99.00
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TAR-T6836-2mg2mg£109.00
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TAR-T6836-5mg5mg£141.00
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TAR-T6836-1mL1 mL * 10 mM (in DMSO)£182.00
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TAR-T6836-10mg10mg£197.00
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TAR-T6836-25mg25mg£315.00
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TAR-T6836-50mg50mg£510.00
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TAR-T6836-100mg100mg£696.00
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Further Information

Bioactivity:
FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.
CAS:
1633044-56-0
Formula:
C35H38N8O4
Molecular Weight:
634.741
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.9934
SMILES:
COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc2N(Cc2ccc(NC(=O)C=C)cc2)C1=O
Target:
FGFR

References

Yang Y L, Cao L B, He W R, et al. Endocytosis triggers V-ATPase-SYK?mediated priming of cGAS activation and innate immune response. Proceedings of the National Academy of Sciences. 2022, 119(43): e2207280119. Tan L, et al. Proc Natl Acad Sci U S A. 2014, 111(45), E4869-4877.