TargetMol

GSK591

Product Code:
 
TAR-T6853
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6853-1mg1mg£103.00
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TAR-T6853-2mg2mg£115.00
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TAR-T6853-5mg5mg£152.00
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TAR-T6853-1mL1 mL * 10 mM (in DMSO)£157.00
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TAR-T6853-10mg10mg£189.00
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TAR-T6853-25mg25mg£309.00
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TAR-T6853-50mg50mg£483.00
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TAR-T6853-100mg100mg£670.00
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TAR-T6853-500mg500mg£1,324.00
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This product comes from: United States.
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Further Information

Bioactivity:
GSK591, Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).
CAS:
1616391-87-7
Formula:
C22H28N4O2
Molecular Weight:
380.492
Pathway:
Chromatin/Epigenetic
Purity:
0.9977
SMILES:
O[C@@H](CNC(=O)c1ccnc(NC2CCC2)c1)CN1CCc2ccccc2C1
Target:
Histone Methyltransferase

References

Elayne Chan-Penebre, et al. Nat Chem Biol. 2015, 11(6):432-437. Li W, He Y, Yang J, et al. Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth[J]. Nature Communications. 2021, 12(1): 1-20 Li W, He Y, Yang J, et al. Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth. Nature Communications. 2021, 12(1): 1-20 SGC. GSK591 A chemical probe for PRMT5.