TargetMol

Halofuginone

Product Code:
 
TAR-T6856
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6856-1mg1mg£95.00
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TAR-T6856-5mg5mg£134.00
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TAR-T6856-1mL1 mL * 10 mM (in DMSO)£141.00
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TAR-T6856-10mg10mg£171.00
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TAR-T6856-25mg25mg£274.00
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TAR-T6856-50mg50mg£377.00
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TAR-T6856-100mg100mg£532.00
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TAR-T6856-500mg500mg£1,083.00
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Further Information

Bioactivity:
Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase?Ki=18.3 nM?, could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
CAS:
55837-20-2
Formula:
C16H17BrClN3O3
Molecular Weight:
414.68
Pathway:
DNA Damage/DNA Repair; Microbiology/Virology; Membrane transporter/Ion channel; Metabolism; Cell Cycle/Checkpoint; Stem Cells
Purity:
0.9767
SMILES:
O[C@@H]1CCCN[C@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
Target:
Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad

References

Keller TL, et al. Nat Chem Biol. 2012, 8(3):311-317. Tsuchida K, et al. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free Radic Biol Med. 2017 Feb;103:236-247. Nelson EF, et al. Molecular Vision. 2012, 18:479-487. McLaughlin NP, et al. Bioorg Med Chem. 2014, 22(7):11993-22004. Jiang S, et al. Antimicrob Agents Chemother. 2005, 49(3):1169-1176.