TargetMol

PF-03814735

Product Code:
 
TAR-T6936
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.
CAS:
942487-16-3
Formula:
C23H25F3N6O2
Molecular Weight:
474.488
Pathway:
Cell Cycle/Checkpoint; Chromatin/Epigenetic; Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
Purity:
0.98
SMILES:
CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1c1cc(Nc3ncc(c(NC4CCC4)n3)C(F)(F)F)ccc21
Target:
FAK; VEGFR; FLT; Trk receptor; Aurora Kinase

References

Jani JP, et al, Mol Cancer Ther, 2010, 9(4), 883-894. Hook KE, et al, Mol Cancer Ther, 2012, 11(3), 710-719.