TargetMol

PF-4989216

Product Code:
 
TAR-T6938
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6938-1mg1mg£103.00
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TAR-T6938-2mg2mg£115.00
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TAR-T6938-5mg5mg£149.00
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TAR-T6938-1mL1 mL * 10 mM (in DMSO)£153.00
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TAR-T6938-10mg10mg£209.00
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TAR-T6938-25mg25mg£335.00
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TAR-T6938-50mg50mg£534.00
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TAR-T6938-100mg100mg£630.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.
CAS:
1276553-09-3
Formula:
C18H13FN6OS
Molecular Weight:
380.4
Pathway:
Apoptosis; PI3K/Akt/mTOR signaling
Purity:
0.9973
SMILES:
Fc1cc(ccc1-c1c(sc(N2CCOCC2)c1C#N)-c1ncn[nH]1)C#N
Target:
Apoptosis; PI3K

References

Walls M, et al. Clin Cancer Res. 2014, 20(3), 631-643. Liao W, Wang Z, Han Y, et al. Design, synthesis and biological activity of novel 2,3,4,5-tetra-substituted thiophene derivatives as PI3K? inhibitors with potent antitumor activity. European Journal of Medicinal Chemistry. 2020, 197: 112309 Liao W, Wang Z, Han Y, et al. Design, synthesis and biological activity of novel 2, 3, 4, 5-tetra-substituted thiophene derivatives as PI3K? inhibitors with potent antitumor activity[J]. European Journal of Medicinal Chemistry. 2020: 112309.