TargetMol

Vps34-PIK-III

Product Code:
 
TAR-T6945
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6945-1mg1mg£108.00
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TAR-T6945-2mg2mg£123.00
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TAR-T6945-1mL1 mL * 10 mM (in DMSO)£165.00
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TAR-T6945-5mg5mg£165.00
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TAR-T6945-10mg10mg£242.00
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TAR-T6945-25mg25mg£454.00
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Quantity:
TAR-T6945-50mg50mg£631.00
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TAR-T6945-100mg100mg£868.00
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Quantity:
TAR-T6945-500mg500mg£1,669.00
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This product comes from: United States.
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Further Information

Bioactivity:
PIK-III, a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.
CAS:
1383716-40-2
Formula:
C17H17N7
Molecular Weight:
319.372
Pathway:
Autophagy; PI3K/Akt/mTOR signaling
Purity:
0.9843
SMILES:
Nc1ncc(c(CC2CC2)n1)-c1ccnc(Nc2ccncc2)n1
Target:
PI3K; Autophagy

References

Honda A, et al. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo. ACS Med Chem Lett. 2015 Nov 13;7(1):72-6. Dowdle WE, et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol. 2014 Nov;16(11):1069-79.