TargetMol

RG7112

Product Code:
 
TAR-T6965
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6965-1mg1mg£103.00
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TAR-T6965-2mg2mg£118.00
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TAR-T6965-5mg5mg£148.00
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TAR-T6965-1mL1 mL * 10 mM (in DMSO)£197.00
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TAR-T6965-10mg10mg£209.00
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TAR-T6965-25mg25mg£346.00
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TAR-T6965-50mg50mg£490.00
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TAR-T6965-100mg100mg£678.00
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TAR-T6965-500mg500mg£1,340.00
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Further Information

Bioactivity:
RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
CAS:
939981-39-2
Formula:
C38H48Cl2N4O4S
Molecular Weight:
727.78
Pathway:
Ubiquitination; Apoptosis
Purity:
0.9992
SMILES:
C[C@@]1(N(C(=O)N2CCN(CCCS(C)(=O)=O)CC2)C(=N[C@@]1(C)C3=CC=C(Cl)C=C3)C4=C(OCC)C=C(C(C)(C)C)C=C4)C5=CC=C(Cl)C=C5
Target:
Mdm2; E1/E2/E3 Enzyme

References

Vu, Binh; Wovkulich, Peter; Pizzolato, Giacomo et al. Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development. ACS Medicinal Chemistry Letters (2013), 4(5), 466-469.