TargetMol

Vps34-IN-1

Product Code:
 
TAR-T7015
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7015-1mg1mg£101.00
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TAR-T7015-2mg2mg£114.00
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TAR-T7015-5mg5mg£139.00
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TAR-T7015-1mL1 mL * 10 mM (in DMSO)£145.00
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TAR-T7015-10mg10mg£177.00
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TAR-T7015-25mg25mg£255.00
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TAR-T7015-50mg50mg£367.00
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TAR-T7015-100mg100mg£497.00
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This product comes from: United States.
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Further Information

Bioactivity:
Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro, which does not significantly inhibit the isoforms of class I as well as class II PI3Ks.
CAS:
1383716-33-3
Formula:
C21H24ClN7O
Molecular Weight:
425.92
Pathway:
Autophagy; PI3K/Akt/mTOR signaling
Purity:
0.9704
SMILES:
CC(C)(O)CNc1ncc(c(CC2CC2)n1)-c1ccnc(Nc2ccnc(Cl)c2)n1
Target:
PI3K; Autophagy

References

Zhang H, Cui Z, Cheng D, et al. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis. Autophagy. 2021 Oct;17(10):3030-3047 Bago R, et al. Biochem J. 2014 Nov 1;463(3):413-27. Zhang H, Cui Z, Cheng D, et al. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis[J]. Autophagy . 2020 Gao Y, Xiong J, Chu Q Z, et al. PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth[J]. Journal of Cell Science. 2021, 135(5): jcs255026.