TargetMol

CU-CPT9b

Product Code:
 
TAR-T7302
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7302-1mg1mg£111.00
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TAR-T7302-2mg2mg£130.00
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TAR-T7302-5mg5mg£168.00
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TAR-T7302-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T7302-10mg10mg£229.00
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TAR-T7302-25mg25mg£367.00
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TAR-T7302-50mg50mg£519.00
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TAR-T7302-100mg100mg£703.00
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Further Information

Bioactivity:
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.
CAS:
2162962-69-6
Formula:
C16H13NO2
Molecular Weight:
251.285
Pathway:
Immunology/Inflammation
Purity:
0.98
SMILES:
Cc1cc(ccc1O)-c1ccnc2cc(O)ccc12
Target:
TLR

References

Yang W, Sun X, Liu S, et al.TLR8 agonist Motolimod-induced inflammatory death for treatment of acute myeloid leukemia.Biomedicine & Pharmacotherapy.2023, 163: 114759. Zhang S , Hu Z , Tanji H , et al. Small-molecule inhibition of TLR8 through stabilization of its resting state[J]. Nature Chemical Biology, 2017, 14(1):58-64.