TargetMol

Vorasidenib

Product Code:
 
TAR-T7307
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7307-1mg1mg£109.00
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TAR-T7307-2mg2mg£128.00
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TAR-T7307-1mL1 mL * 10 mM (in DMSO)£158.00
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TAR-T7307-5mg5mg£168.00
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TAR-T7307-10mg10mg£230.00
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TAR-T7307-25mg25mg£374.00
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TAR-T7307-50mg50mg£527.00
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TAR-T7307-100mg100mg£725.00
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This product comes from: United States.
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Further Information

Bioactivity:
Vorasidenib is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)
CAS:
1644545-52-7
Formula:
C14H13ClF6N6
Molecular Weight:
414.74
Pathway:
Metabolism
Purity:
0.98
SMILES:
C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F
Target:
Isocitrate Dehydrogenase (IDH)

References

Zakkula A, Dittakavi S, Maniyar MM,et al.Validated HPLC method for simultaneous quantification of mutant IDH1/2 inhibitors (enasidenib, ivosidenib and vorasidenib) in mouse plasma: Application to a pharmacokinetic study[J].Biomed Chromatogr. 2019 Nov;33(11):e4658. Tianfang M , Fangxia Z , Stefan P , et al. Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): an Update and Perspective[J]. Journal of Medicinal Chemistry, 2018:acs.jmedchem.8b00159-.