TargetMol

ICA-121431

Product Code:
 
TAR-T7336
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7336-2mg2mg£103.00
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TAR-T7336-5mg5mg£122.00
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TAR-T7336-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T7336-10mg10mg£143.00
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TAR-T7336-25mg25mg£197.00
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TAR-T7336-50mg50mg£283.00
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Quantity:
TAR-T7336-100mg100mg£390.00
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This product comes from: United States.
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Further Information

Bioactivity:
ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.
CAS:
313254-51-2
Formula:
C23H19N3O3S2
Molecular Weight:
449.54
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)C(c1ccccc1)c1ccccc1
Target:
Sodium Channel

References

Mccormack K , Santos S , Chapman M L , et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels[J]. Proceedings of the National Academy of Sciences, 2013, 110(29):E2724-E2732. Song G , Yang D , Wang Y , et al. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators[J]. Nature, 2017.