TargetMol

Talarozole

Product Code:
 
TAR-T7370
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7370-1mg1mg£124.00
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TAR-T7370-2mg2mg£148.00
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TAR-T7370-1mL1 mL * 10 mM (in DMSO)£161.00
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TAR-T7370-5mg5mg£181.00
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TAR-T7370-10mg10mg£213.00
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TAR-T7370-25mg25mg£300.00
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TAR-T7370-50mg50mg£386.00
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TAR-T7370-100mg100mg£540.00
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This product comes from: United States.
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Further Information

Bioactivity:
Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of acne, psoriasis and other keratinization disorders.
CAS:
201410-53-9
Formula:
C21H23N5S
Molecular Weight:
377.51
Pathway:
Metabolism; ; Autophagy
Purity:
0.98
SMILES:
CCC(CC)C(c1ccc(Nc2nc3ccccc3s2)cc1)n1cncn1
Target:
P45; Retinoid Receptor; Autophagy

References

Elizabeth Pavez Lori?, Li H , Vahlquist A , et al. The involvement of cytochrome p450 (CYP) 26 in the retinoic acid metabolism of human epidermal keratinocytes[J]. Biochim Biophys Acta, 2009, 1791(3):0-228. Elizabeth Pavez Lori?, Chamcheu J C , Vahlquist A , et al. Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis[J]. Archives of Dermatological Research, 2009, 301(7):475-485.