TargetMol

LF3

Product Code:
 
TAR-T7399
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7399-2mg2mg£95.00
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TAR-T7399-5mg5mg£109.00
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TAR-T7399-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T7399-10mg10mg£130.00
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TAR-T7399-25mg25mg£191.00
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TAR-T7399-50mg50mg£282.00
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TAR-T7399-100mg100mg£389.00
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This product comes from: United States.
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Further Information

Bioactivity:
LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)
CAS:
664969-54-4
Formula:
C20H24N4O2S2
Molecular Weight:
416.56
Pathway:
Cytoskeletal Signaling; Stem Cells
Purity:
0.98
SMILES:
NS(=O)(=O)c1ccc(NC(=S)N2CCN(CC=Cc3ccccc3)CC2)cc1
Target:
Wnt/beta-catenin

References

Zhao L, Sun L, Lu Y,ea al.A small-molecule LF3 abrogates ?-catenin/TCF4-mediated suppression of NaV1.5 expression in HL-1 cardiomyocytes[J].J Mol Cell Cardiol. 2019 Oct;135:90-96. Fang L , Zhu Q , Neuenschwander M , et al. A Small-Molecule Antagonist of the ?-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis[J]. Cancer Research, 2015, 76(4):891-901.