TargetMol

J14

Product Code:
 
TAR-T8320
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8320-2mg2mg£104.00
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TAR-T8320-5mg5mg£125.00
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TAR-T8320-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T8320-10mg10mg£148.00
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TAR-T8320-25mg25mg£197.00
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TAR-T8320-50mg50mg£265.00
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Quantity:
TAR-T8320-100mg100mg£401.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death
CAS:
1043854-13-2
Formula:
C28H25ClN4O2S
Molecular Weight:
517.04
Pathway:
Immunology/Inflammation; Metabolism; NF-κb
Purity:
0.9781
SMILES:
OC(=O)c1ccc(CSc2nc(cc(n2)-c2ccccc2)N2CCN(CC2)c2ccccc2Cl)cc1
Target:
Reactive Oxygen Species

References

Kim H, et al. Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damage. Free Radic Biol Med. 2016 Feb;91:264-74.