TargetMol

Tenovin-6 Hydrochloride

Product Code:
 
TAR-T8480
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8480-1mg1mg£97.00
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TAR-T8480-2mg2mg£108.00
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TAR-T8480-5mg5mg£122.00
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TAR-T8480-1mL1 mL * 10 mM (in DMSO)£124.00
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TAR-T8480-10mg10mg£135.00
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TAR-T8480-25mg25mg£185.00
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TAR-T8480-50mg50mg£262.00
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TAR-T8480-100mg100mg£389.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .
CAS:
1011301-29-3
Formula:
C25H35ClN4O2S
Molecular Weight:
491.09
Pathway:
Chromatin/Epigenetic; Autophagy; Apoptosis; DNA Damage/DNA Repair; Metabolism
Purity:
1
SMILES:
Cl.CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1
Target:
Dehydrogenase; Sirtuin; HDAC; p53; Autophagy

References

Dai W, et al. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma. Sci Rep. 2016 Mar 4;6:22622. Yuan H, et al. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017 Feb 9;8(2):e2608.