TargetMol

ML318

Product Code:
 
TAR-T8533
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8533-1mg1mg£111.00
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TAR-T8533-2mg2mg£130.00
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TAR-T8533-5mg5mg£168.00
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TAR-T8533-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T8533-10mg10mg£230.00
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TAR-T8533-25mg25mg£430.00
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TAR-T8533-50mg50mg£599.00
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TAR-T8533-100mg100mg£824.00
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Further Information

Bioactivity:
ML318 is a biaryl nitrile PvdQ acylase inhibitor (IC50 of 20 nM for binding in the acyl-binding site). ML318 inhibits P. aeruginosa (PAO1) with IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions.
CAS:
1610516-67-0
Formula:
C14H8F4N2
Molecular Weight:
280.226
Pathway:
; Microbiology/Virology
Purity:
0.9865
SMILES:
Fc1ccc(cc1)C(C#N)c1cccc(n1)C(F)(F)F
Target:
Antibiotic

References

Jacqueline M Wurst, et al. Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine. ACS Chem Biol. 2014 Jul 18;9(7):1536-44.