TargetMol

KCC-07

Product Code:
 
TAR-T8554
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8554-1mg1mg£98.00
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Quantity:
TAR-T8554-2mg2mg£109.00
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TAR-T8554-5mg5mg£128.00
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TAR-T8554-1mL1 mL * 10 mM (in DMSO)£131.00
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TAR-T8554-10mg10mg£172.00
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TAR-T8554-25mg25mg£269.00
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Quantity:
TAR-T8554-50mg50mg£386.00
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Quantity:
TAR-T8554-100mg100mg£540.00
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Quantity:
TAR-T8554-500mg500mg£1,091.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling.
CAS:
315702-75-1
Formula:
C14H11N3OS
Molecular Weight:
269.32
Pathway:
DNA Damage/DNA Repair
Purity:
0.9993
SMILES:
Oc1cccc(Nc2nc(cs2)-c2ccccn2)c1
Target:
DNA Alkylator/Crosslinker

References

Dan Zhu, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 From Mdm2-Mediated Degradation. Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5.