TargetMol

Apcin

Product Code:
 
TAR-T8561
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8561-1mg1mg£103.00
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TAR-T8561-2mg2mg£116.00
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TAR-T8561-5mg5mg£142.00
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TAR-T8561-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T8561-10mg10mg£185.00
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TAR-T8561-25mg25mg£302.00
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TAR-T8561-50mg50mg£470.00
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TAR-T8561-100mg100mg£671.00
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Further Information

Bioactivity:
Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blocking mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe.
CAS:
300815-04-7
Formula:
C13H14Cl3N7O4
Molecular Weight:
438.65
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9674
SMILES:
Cc1ncc(n1CCOC(=O)NC(Nc1ncccn1)C(Cl)(Cl)Cl)[N+]([O-])=O
Target:
APC

References

Katharine L Sackton, et al. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature. 2014 Oct 30;514(7524):646-9. Katherine V Richeson, et al. Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C Cdc20. Nat Chem Biol. 2020 May;16(5):546-555.